Miguel Cotto
Up to that time this was PacMan’s biggest test. Although Cotto was coming off of a defeat at the hands of Antonio Margarito, he was still considered a formidable opponent. Cotto was a legitimate welterweight, in his prime with a solid boxing pedigree. None of which were a problem for Pacquiao. Much as he did to De La Hoya, he dismantled Cotto stopping him in the twelfth round. The fight also made Manny the first fighter to win a world-title belt in seven different weight classes.